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Applications of microdialysis in pharmaceutical science

Corporate Author: ebrary, Inc.
Other Authors: Tsai, Tung-Hu.
Format: Book
Language:English
Published: Hoboken, N.J. : Wiley, c2011.
Subjects:
Pharmaceutical chemistry.
Drug development.
Online Access:http://site.ebrary.com/lib/ucy/Doc?id=10484651
Table of Contents:
  • Machine generated contents note: Chapter 1: Introduction to Applications of Microdialysis in Pharmaceutical Sciences.
  • Chapter 2: Microdialysis in Drug Discovery.
  • 1. Introduction.
  • 2. Phases of Drug Development.
  • 3. Role of Biomarkers in Drug Development.
  • 4. Role of Pharmacokinetic-Pharmacodynamic Modeling in Drug Development.
  • 5. Role of Microdialysis in Drug Development.
  • 6. Current Applications and Perspective of Microdialysis Sampling for Drug Development of Specific Therapeutic Groups.
  • 7. Regulary Aspects of Microdialysis Sampling in Drug Development.
  • 8. Conclusions.
  • Chapter 3: Analytical Considerations for Microdialysis Sampling.
  • 1. Introduction.
  • 2 Analytical Methodologies.
  • Chapter 4: Monitoring Dopamine in the mesocorticolimbic and nigrostriatal systems by microdialysis: relevance for mood disorders and Parkinson's disease.
  • 1. Introduction.
  • 2. Pathophysiology of Serotonin-Dopamine Interaction: Implication for Mood Disorders.
  • 3. Dopamine Depletion in the Nigrostriatal System: Parkinson'S Disease.
  • 4. Conclusions.
  • Chapter 5: Monitoring Neurotransmitter Amino Acids by Microdialysis: Pharmacodynamic Applications.
  • 1. Introduction.
  • 2. Monitoring neurotransmitter amino acids by microdialysis.
  • 3. Basic Research on receptors.
  • 4. Psychostimulants and addictive drugs.
  • 5. Analgesia.
  • 6. Ischemia/ anoxia.
  • 7. Conclusion and perspectives.
  • Chapter 6: Microdialysis as a tool to unravel neurobiological mechanisms of seizures and antiepileptic drug action.
  • 1. Introduction.
  • 2. Microdialysis to characterise the seizure-related neurobiological and metabolic changes in animal models and in humans.
  • 3. Microdialysis as chemoconvulsant delivery tool in animal seizure models.
  • 4. Microdialysis as an elegant tool to elucidate mechanisms of electrical brain stimulation and neuronal circuits involved in the generation and control of seizures.
  • 5. Microdialysis to unravel the mechanisms of action of established antiepileptic drugs and new therapeutic strategies.
  • 6. Microdialysis studies in search for mechanisms of adverse effects of clinically used drugs, drugs of abuse and toxins.
  • 7. Combination of microdialysis with other complementary neurotechniques to unravel mechanisms of seizures and epilepsy.
  • 8. The advantage of microdialysis to sample biophase levels of antiepileptic drugs and to monitor central neurotransmitters as pharmacodynamic markers for their anticonvulsant activity.
  • 9. Microdialysis as a tool to study relationships between epilepsy and its comorbidities.
  • Chapter 7: Microdialysis in lung: Monitoring of exogenous and endogenous compounds.
  • 1. Introduction.
  • 2. Special aspects associated with lung microdialysis compared to microdialysis in other tissues.
  • 3. Insertion of microdialysis probes into lung tissue.
  • 4. Insertion of microdialysis probes in the bronchial system.
  • 5. Types of probes.
  • 6. Endogenous compounds.
  • 7. Exogenous drugs.
  • 8. Animal data.
  • 9. Clinical data.
  • 10. Comparison of pharmacokinetic data in lung obtained by microdialysis and other techniques.
  • 11. Predictability of lung concentrations by measurements in other tissues.
  • Chapter 8: Microdialysis in the hepatobiliary system: Monitoring drug metabolism, hepatobiliary excretion and enterohepatic circulation.
  • 1. Introduction.
  • 2. Experimental considerations of pharmacokinetic studies.
  • 3. Pharmacokinetic and hepatobiliary excretion studies employing microdialysis.
  • 4. Conclusions.
  • Chapter 9: Microdialysis on the metabolism of glucose, lactate and glycerol.
  • 1. Introduction.
  • 2. Glucose.
  • 3. Lactate.
  • 4. Lactate/pyruvate ratio.
  • 5. Glycerol.
  • Chapter 10: Clinical microdialysis in skin and soft tissues.
  • 1. Introduction.
  • 2. Tissue Bioavailability.
  • 3. PK/PD Indices.
  • 4. Topical Bioequivalence.
  • 5. Endogenous Compounds.
  • 6. Conclusion.
  • Chapter 11: Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans.
  • 1. Introduction.
  • 2. Principle and Practical Considerations for Application of Microdialysis on Adipose Tissue.
  • 3. Application of Microdialysis on Adipose Tissue in Humans.
  • 4. Summary and Conclusions.
  • Chapter 12: Microdialysis as a monitoring system for human diabetes.
  • 1. Introduction.
  • 2. Monitoring of the acute complications of diabetes.
  • Chapter 13: Microdialysis in Tumors: Drug Disposition and Tumor Response.
  • 1. Introduction.
  • 2. Considerations of microdialysis as a sampling technique in oncology.
  • 3. Experimental considerations.
  • 4. Examples of using microdialysis techniques to characterize drug disposition in tumor.
  • 5. Application of microdialysis in evaluation of tumor response to therapy.
  • 6. Conclusions and future perspective.
  • Chapter 14: Microdialysis versus imaging techniques for in vivo drug distribution measurements.
  • 1. Introduction.
  • 2. Microdialysis.
  • 3. Imaging techniques.
  • 4. Magnetic resonance imaging and magnetic resonance spectroscopy.
  • 5. Positron Emission Tomography (PET).
  • 6. Combination of Microdialysis and Imaging Techniques.
  • 7. Summary and Conclusion.
  • Chapter 15: In vitro applications of microdialysis.
  • 1. Introduction.
  • 2. Microdialysis applied in culture systems.
  • 3. Microdialysis applied in enzyme kinetics.
  • 4. Microdialysis applied in protein binding.
  • 5. Conclusions.
  • Chapter 16: Microdialysis in Drug-Drug Interaction.
  • 1. Introduction.
  • 2. Pharmacokinetic drug interaction.
  • 3. Pharmacodynamic drug interaction.
  • 4. Conclusions.
  • Chapter 17. Microdialysis in environmental monitoring.
  • 1. Introduction.
  • 2. In-vivo sampling vis-αa-vis in-situ sampling: Similarities and differences.
  • 3. Critical parameters influencing relative recoveries.
  • 4. Detection techniques.
  • 5. Calibration methods.
  • 6. Environmental applications of microdialysis.
  • 7. Conclusions and future trends.

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